Synthesis of an optically active template for 4'-substituted nucleoside analogs via chromium carbene complex photochemistry

被引：24

作者：

Reed, AD ^{[1
]}

Hegedus, LS ^{[1
]}

机构：

[1] COLORADO STATE UNIV,DEPT CHEM,FT COLLINS,CO 80523

来源：

ORGANOMETALLICS | 1997年 / 16卷 / 11期

关键词：

D O I：

10.1021/om970069o

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Procedures for the efficient synthesis and handling of [ethoxy((benzyloxy)methyl)carbene]pentacarbonylchromium(0) have been developed. Photolysis in the presence of the optically active ene carbamate 12 followed by Baeyer-Villiger oxidation and oxazolidinone elimination gave (R)-(+)-5-ethoxy-5-((benzyloxy)methyl)-2(5H)-furanone in good yield and with high enantiomeric purity. This compound provides a potential template for the synthesis of 4'-substituted nucleoside analogs.

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页码：2313 / 2317

页数：5

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