Association of anti-GM(2) antibodies in Guillain-Barre syndrome with acute cytomegalovirus infection

被引：77

作者：

Irie, S ^{[1
]}

Saito, T ^{[1
]}

Nakamura, K ^{[1
]}

Kanazawa, N ^{[1
]}

Ogino, M ^{[1
]}

Nukazawa, T ^{[1
]}

Ito, H ^{[1
]}

Tamai, Y ^{[1
]}

Kowa, H ^{[1
]}

机构：

[1] KITASATO UNIV, SCH MED, DEPT BIOCHEM, SAGAMIHARA, KANAGAWA 228, JAPAN

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1996年 / 68卷 / 1-2期

关键词：

anti-GM(2) antibody; Guillain-Barre syndrome; cytomegalovirus;

D O I：

10.1016/0165-5728(96)00059-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We examined serum anti-cytomegalovirus (CMV) and anti-ganglioside antibodies by ELISA in 51 patients with Guillain-Barre syndrome (GBS), and titers were compared with those from 47 normal and 74 disease controls. Three GBS patients with IgM anti-CMV antibodies had high titers of IgM and IgG anti-GM(2) antibodies. The other GBS patients without IgM anti-CMV antibodies, and the normal and disease controls except one of 6 non-GBS patients with acute CMV infections had no anti-GM(2) antibodies. The titers of anti-CM(2) antibodies decreased on absorption with CMV-infected cells. These findings suggest that anti-GM(2) antibodies are associated with acute CMV infections in GBS patients.

引用

页码：19 / 26

页数：8

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