Solid-phase synthesis of diverse tetrahydro-1,4-benzodiazepine-2-ones

被引：26

作者：

Bhalay, G

Blaney, P

Palmer, VH

Baxter, AD

机构：

[1] Oxford Diversity, A Division of Oxford Asymmetry Ltd., Abingdon, Oxon, OX14 4RX

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 48期

关键词：

D O I：

10.1016/S0040-4039(97)10170-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general method for the construction of tetrahydro-1,4-benzodiazepine-2-ones on solid-support has been developed utilising a cleavage-conjugate addition protocol as the key step in the design. Using this novel methodology the synthesis of a diverse one hundred and twenty compound library with three points of diversity has been achieved starting from readily available anthranilic esters. (C) 1997 Elsevier Science Ltd.

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页码：8375 / 8378

页数：4

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