Modulation of the age at onset of Parkinson's disease by apolipoprotein E genotypes

被引：50

作者：

Zareparsi, S

Kaye, J

Camicioli, R

Grimslid, H

Oken, B

Litt, M

Nutt, J

Bird, T

Schellenberg, G

Payami, H

机构：

[1] OREGON HLTH SCI UNIV,DEPT NEUROL,PORTLAND,OR 97201

[2] OREGON HLTH SCI UNIV,DEPT BIOCHEM & MOL BIOL,PORTLAND,OR 97201

[3] PORTLAND VET AFFAIRS MED CTR,PORTLAND,OR

[4] UNIV WASHINGTON,DEPT NEUROL,SEATTLE,WA 98195

[5] UNIV WASHINGTON,DEPT MED,SEATTLE,WA 98195

[6] UNIV WASHINGTON,DEPT PHARMACOL,SEATTLE,WA 98195

来源：

ANNALS OF NEUROLOGY | 1997年 / 42卷 / 04期

关键词：

D O I：

10.1002/ana.410420417

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Parkinson's disease (PD) patients often develop dementia, and Alzheimer's disease (AD) patients frequently develop parkinsonian signs. The apolipoprotein E epsilon 4 allele is associated with increased risk and earlier onset of AD. We studied 137 unrelated white PD patients. Those with epsilon 4 had the earliest onset (52.7 +/- 9.8 years), epsilon 3/epsilon 3 patients had an intermediate onset (56.1 +/- 11.1 years), and those with epsilon 2 had the latest onset (59.1 +/- 13.4 years). The age at onset distribution for epsilon 4/epsilon- was significantly earlier than for epsilon 3/epsilon 3 and epsilon 2/epsilon 3. These preliminary results suggest that apolipoprotein E genotypes modulate the age at onset of PD.

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页码：655 / 658

页数：4

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