Catalytic asymmetric carbonyl-ene reactions with alkynylogous and vinylogous glyoxylates: Application to controlled synthesis of chiral isocarbacyclin analogues

被引：34

作者：

Mikami, K

Yoshida, A

Matsumoto, Y

机构：

[1] Department of Chemical Technology, Tokyo Institute of Technology, Tokyo 152, Meguro-ku

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 47期

关键词：

D O I：

10.1016/0040-4039(96)01954-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The asymmetric carbonyl-ene reaction with alkynylogous and vinylogous glyoxylates (1, 2) catalyzed by a binaphthol-derived chiral titanium complex is described. The catalytic asymmetric ene reaction with aldehyde (I) can be applied to the double asymmetric synthesis of isocarbacyclin analogues bearing a 2-allenyl side chain. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：8515 / 8518

页数：4

共 35 条

[1]

[Anonymous], 1992, Org. Synth

[2] SYNTHESIS OF THERAPEUTICALLY USEFUL PROSTAGLANDIN AND PROSTACYCLIN ANALOGS [J].