New steroidal alkaloids from Fritillaria imperialis and their cholinesterase inhibiting activities

被引：61

作者：

Atta-ur-Rahman

Akhtar, MN

Choudhary, MI ^{[1
]}

Tsuda, Y

Sener, B

Khalid, A

Parvez, M

机构：

[1] Univ Karachi, Int Ctr Chem Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan

[2] Gazi Univ, Fac Pharm, Dept Pharmacognosy, TR-06330 Ankara, Turkey

[3] Univ Calgary, Fac Sci, Dept Chem, Calgary, AB, Canada

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2002年 / 50卷 / 08期

关键词：

Fritillaria imperialis; impericine; forticine; cevanine-type; acetylcholinesterase; butyrylcholinesterase;

D O I：

10.1248/cpb.50.1013

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Two new cevanine steroidal alkaloids, impericine (1) and forticine (2) along with known bases delavine (3), persicanidine A (4), and imperialine (5) were isolated from the bulbs of Fritillaria imperialis. The structures of impericine (1) [(20R,22S,25S)-5alpha-cevanin-23-ene-3beta,6beta,16beta,8-triol] and forticine (2) [(20S,22S,25S)-5alpha-cevanine-3beta,6beta-diol] were determined with the help of spectroscopic studies. These steroidal bases showed anti-acetylcholinesterase and anti-butyrylcholinesterase inhibitory activity.

引用

页码：1013 / 1016

页数：4

共 18 条

[1]

Atta-ur-Rahman, 1998, HETEROCYCLES, V49, P481

[2]

ATTAURRAHMAN, 1994, PLANTA MED, V60, P377, DOI 10.1055/s-2006-959507

[3]

LUPINEN-ALKALOIDE .8. ZUR KONFIGURATIONSBESTIMMUNG VON CHINOLIZIDIN-DERIVATEN [J].