5-HT4 receptor enhances the propulsive power of the peristaltic reflex in the rat distal colon

被引：22

作者：

Kadowaki, M ^{[1
]}

Wang, XB ^{[1
]}

Shimatani, H ^{[1
]}

Yoneda, S ^{[1
]}

Takaki, M ^{[1
]}

机构：

[1] Nara Med Univ, Dept Physiol 2, Nara 6348521, Japan

来源：

AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL | 2002年 / 99卷 / 01期

关键词：

rat; distal colon; peristaltic reflex; 5-HT4; receptor; agonist; mosapride;

D O I：

10.1016/S1566-0702(02)00063-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study was designed to investigate the nature of the 5-HT4 receptors affecting the peristaltic reflex in the isolated rat distal colon. A single peristaltic reflex was evoked by infusing Tyrode solution into the lumen of the isolated segment using our modified Trendelenburg's method under an isovolumic condition. A 5-HT4 receptor agonist, mosapride (10 nM), did not affect the threshold pressure and the propagation distance of the reflex contraction, but significantly increased the developed pressure (maximum pressure - threshold pressure) from 19.1 +/- 11.8 cm H2O in the control to 26.8 +/- 13.0 cm H2O (n = 8, P < 0.05) without affecting the resting muscle tone in the distal colon. The present result suggests that stimulation of 5-HT4 receptor enhances the propulsive power to move the luminal contents in the rat distal colon. (C) 2002 Elsevier Science B.V All rights reserved.

引用

页码：62 / 65

页数：4

共 24 条

[1] Evaluation of gastric emptying and motility in diabetic gastroparesis with magnetic resonance imaging: Effects of cisapride [J].