Antitumor diarylsulfonylureas: Novel agents with unfulfilled promise

被引：33

作者：

Houghton, PJ

Houghton, JA

机构：

[1] Department of Molecular Pharmacology, St. Jude Children's Research Hospital, Memphis

[2] Dept. Molecular Pharmacology, St Jude Children's Research Hospital, Memphis, TN 38105-2794, N. Lauderdale

来源：

INVESTIGATIONAL NEW DRUGS | 1996年 / 14卷 / 03期

关键词：

diarylsulfonylureas; xenografts; pharmacology;

D O I：

10.1007/BF00194530

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Diarylsulfonylureas represent a class of antitumor agent with significant therapeutic efficacy against rodent and human models of cancer. Despite the exciting preclinical activity of sulofenur, the prototypic agent, clinical activity was poor. Here we review the activity of sulofenur and a second generation diarylsulfonylurea, LY295501 N-[5-(2,3-dihydrobenzofuryl) sulfonyl]-N'-(3,4-dichlorophenyl)urea, against colon tumor xenografts, and some of the cellular pharmacology of this class of antitumor agents.

引用

页码：271 / 280

页数：10

共 34 条

[1] PHASE-I TRIAL OF SULOFENUR (LY186641) GIVEN ORALLY ON A DAILY X 21 SCHEDULE [J].

BROWN, TD ;

OROURKE, TJ ;

KUHN, JG ;

CRAIG, JB ;

HAVLIN, K ;

BURRIS, HA ;

CAGNOLA, J ;

HAMILTON, JM ;

GRINDEY, GB ;

SATTERLEE, WG ;

VONHOFF, DD .

ANTI-CANCER DRUGS, 1994, 5 (02) :151-159

[2]

EHLHARDT WJ, 1992, DRUG METAB DISPOS, V20, P958

[3]

EHLHARDT WJ, 1991, DRUG METAB DISPOS, V19, P370

[4]

EHLHARDT WJ, 1991, DRUG METAB DISPOS, V19, P366

[5]

GRINDEY GB, 1988, P AM ASSOC CANC RES, V29, pA535

[6]

GU H, 1994, P AM ASSOC CANC RES, V35, pA1917

[7]

GU H, 1994, P AM ASSOC CANC RES, V35, pA1918

[8]

HAINSWORTH JD, 1989, CANCER RES, V49, P5217

[9]

HOUGHTON P, 1991, 3RD P INT C NEOADJ C, P405

[10] CHARACTERIZATION OF THE INTRACELLULAR-DISTRIBUTION AND BINDING IN HUMAN ADENOCARCINOMA CELLS OF N-(4-AZIDOPHENYLSULFONYL)-N'-(4-CHLOROPHENYL)UREA (LY219703), A PHOTOAFFINITY ANALOG OF THE ANTITUMOR DIARYLSULFONYLUREA SULOFENUR [J].

HOUGHTON, PJ ;

SOSINSKI, J ;

THAKAR, JH ;

BODER, GB ;

GRINDEY, GB .

BIOCHEMICAL PHARMACOLOGY, 1995, 49 (05) :661-668

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