Rimonabant induces partial seizures in a patient with a history of generalized epilepsy

被引:22
作者
Braakman, Hilde M. H. [1 ]
van Oostenbrugge, Robert J. [1 ,2 ]
van Kranen-Mastenbroek, Vivianne H. J. M. [2 ,3 ]
de Krom, Marc C. T. F. M. [1 ]
机构
[1] Maastricht Univ Med Ctr, Dept Neurol, Maastricht, Netherlands
[2] Maastricht Univ, European Grad Sch Neurosci EURON, Maastricht, Netherlands
[3] Maastricht Univ Med Ctr, Dept Clin Neurophysiol, Maastricht, Netherlands
关键词
ENDOCANNABINOID SYSTEM; RISK-FACTORS; HIPPOCAMPUS; OVERWEIGHT; RECEPTOR;
D O I
10.1111/j.1528-1167.2009.02203.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
引用
收藏
页码:2171 / 2172
页数:2
相关论文
共 6 条
[1]   Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia [J].
Despres, JP ;
Golay, A ;
Sjostrom, L .
NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (20) :2121-2134
[2]   Downregulation of the CB1 cannabinoid receptor and related molecular elements of the endocannabinoid system in epileptic human hippocampus [J].
Ludanyi, Aniko ;
Eross, Lorand ;
Czirjak, Sandor ;
Vajda, Janos ;
Halasz, Peter ;
Watanabe, Masahiko ;
Palkovits, Miklos ;
Magloczky, Zsofia ;
Freund, Tamas F. ;
Katona, Istvan .
JOURNAL OF NEUROSCIENCE, 2008, 28 (12) :2976-2990
[3]   The endocannabinoid system controls key epileptogenic circuits in the hippocampus [J].
Monory, Krisztina ;
Massa, Federico ;
Egertova, Michaela ;
Eder, Matthias ;
Blaudzun, Heike ;
Westenbroek, Ruth ;
Kelsch, Wolfgang ;
Jacob, Wolfgang ;
Marsch, Rudolf ;
Ekker, Marc ;
Long, Jason ;
Rubenstein, John L. ;
Goebbels, Sandra ;
Nave, Klaus-Armin ;
During, Matthew ;
Klugmann, Matthias ;
Woelfel, Barbara ;
Dodt, Hans-Ulrich ;
Zieglgaensberger, Walter ;
Wotjak, Carsten T. ;
Mackie, Ken ;
Elphick, Maurice R. ;
Marsicano, Giovanni ;
Lutz, Beat .
NEURON, 2006, 51 (04) :455-466
[4]   Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients - RIO-North America: A randomized controlled trial [J].
Pi-Sunyer, F ;
Aronne, LJ ;
Heshmati, HM ;
Devin, J ;
Rosenstock, J .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2006, 295 (07) :761-775
[5]   Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomised controlled study [J].
Scheen, Andre J. ;
Finer, Nick ;
Hollander, Priscilla ;
Jensen, Michael D. ;
Van Gaal, Luc F. .
LANCET, 2006, 368 (9548) :1660-1672
[6]   Evidence for a physiological role of endocannabinoids in the modulation of seizure threshold and severity [J].
Wallace, MJ ;
Martin, BR ;
DeLorenzo, RJ .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2002, 452 (03) :295-301