An allosteric crown ether-induced activity control for the cleavage of a phosphodiester bond

被引：23

作者：

Tozawa, T ^{[1
]}

Tokita, S ^{[1
]}

Kubo, Y ^{[1
]}

机构：

[1] Saitama Univ, Fac Engn, Dept Appl Chem, Sakura Ku, Saitama, Saitama 3388570, Japan

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 19期

关键词：

crown compounds; allosteric control; phosphodiester cleavage; supramolecular chemistry;

D O I：

10.1016/S0040-4039(02)00601-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bis (thiourea) receptor 1 based on a highly flexible dibenzo-diaza-30-crown-10 scaffold represented a K+-organized microenvironment to markedly accelerate the cleavage of the phoshodiester linkage of the RNA model substrate (2-hydroxypropyl-p-nitrophenyl phosphate). (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：3455 / 3457

页数：3

共 21 条

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[2]

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[3]

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