Influence of origin of isolates, especially endocarditis isolates, and various genes on biofilm formation by Enterococcus faecalis

被引:236
作者
Mohamed, JA
Huang, W
Nallapareddy, SR
Teng, F
Murray, BE
机构
[1] Univ Texas, Sch Med, Ctr Study Emerging & Reemerging Pathogens, Div Infect Dis, Houston, TX 77030 USA
[2] Univ Texas, Sch Med, Dept Internal Med, Div Infect Dis, Houston, TX 77030 USA
[3] Univ Texas, Sch Med, Dept Microbiol & Mol Genet, Houston, TX 77030 USA
关键词
D O I
10.1128/IAI.72.6.3658-3663.2004
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Endocarditis isolates of Enterococcus faecalis produced biofilm significantly more often than nonendocarditis isolates, and 39% of 79 versus 6% of 84 isolates produced strong biofilm (P < 0.0001). esp was not required, but its presence was associated with higher amounts of biofilm (P < 0.001). Mutants disrupted in dltA, efaA, ace, lsa, and six two-component regulatory systems were largely unaltered, while disruptions in epa, atn, gelE, and fir resulted in fewer attached bacteria, as determined using phase-contrast microscopy, and less biofilm (P < 0.0001).
引用
收藏
页码:3658 / 3663
页数:6
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