Hyperinvasive neonatal group B streptococcus has arisen from a bovine ancestor

被引:119
作者
Bisharat, N
Crook, DW
Leigh, J
Harding, RM
Ward, PN
Coffey, TJ
Maiden, MC
Peto, T
Jones, N
机构
[1] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Lab Sci, Oxford OX3 9DU, England
[2] Univ Oxford, John Radcliffe Hosp, Peter Medawar Bldg Pathogen Res, Oxford OX3 9DU, England
[3] Univ Oxford, John Radcliffe Hosp, Acad Dept Microbiol & Infect Hlth, Oxford OX3 9DU, England
[4] Inst Food Res, Inst Anim Hlth, Compton Lab, Newbury RG16 0NN, Berks, England
基金
英国生物技术与生命科学研究理事会;
关键词
D O I
10.1128/JCM.42.5.2161-2167.2004
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The genetic relatedness and evolutionary relationships between group B streptococcus (GBS) isolates from humans and those from bovines were investigated by phylogenetic analysis of multilocus sequence typing data. The collection of isolates consisted of 111 GBS isolates from cows with mastitis and a diverse global collection of GBS isolates from patients with invasive disease (n = 83) and carriers (n = 69). Cluster analysis showed that the majority of the bovine isolates (93%) grouped into one phylogenetic cluster. The human isolates showed greater diversity and clustered separately from the bovine population. However, the homogeneous human sequence type 17 (ST-17) complex, known to be significantly associated with invasive neonatal disease, was the only human lineage found to be clustered within the bovine population and was distinct from all the other human lineages. Split decomposition analysis revealed that the human isolate ST-17 complex, the major hyperinvasive neonatal clone, has recently arisen from a bovine lineage.
引用
收藏
页码:2161 / 2167
页数:7
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