A controlled clinical trial of sertraline in the treatment of depression in nursing home patients with late-stage Alzheimer's disease

被引：105

作者：

Magai, C ^{[1
]}

Kennedy, G ^{[1
]}

Cohen, CI ^{[1
]}

Gomberg, D ^{[1
]}

机构：

[1] Long Isl Univ, Dept Psychol, Brooklyn, NY 11201 USA

来源：

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY | 2000年 / 8卷 / 01期

关键词：

D O I：

10.1097/00019442-200002000-00009

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

A sample of 31 female nursing home patients with late-stage Alzheimer's disease participated in a double-blind clinical trial of the antidepressant medication sertraline. Measures of depression included various objective scales and two measures of facial expressions of emotion coded during a semistructured interview using a facial affect coding system. Repeated-measures ANOVAs at baseline and mt the 8-week endpoint indicated that on all measures, both the treatment and placebo groups improved over time, with three of six measures showing a significant time effect. The "knit-brow" facial measure approached significance for a Treatment x rime effect. thus, sertraline had no significant benefits over placebo. However, if as we hypothesize, the knit-brow response is more sensitive to signs of depression in advanced dementia, our study justifies the further investigation of the use of sertraline in this population.

引用

页码：66 / 74

页数：9

共 38 条

[1] CORNELL SCALE FOR DEPRESSION IN DEMENTIA [J].