Targeting XBP-1 as a novel anti-cancer strategy

被引：122

作者：

Koong, Albert C. ^{[1
]}

Chauhan, Vibha ^{[1
]}

Romero-Ramirez, Lorenzo ^{[1
]}

机构：

[1] Stanford Univ, Dept Radiat Oncol, Stanford, CA 94305 USA

来源：

CANCER BIOLOGY & THERAPY | 2006年 / 5卷 / 07期

关键词：

unfolded protein response; hypoxia; tumor microenvironment; IRE1; XBP-1;

D O I：

10.4161/cbt.5.7.2973

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The survival and growth of tumor cells within the microenvironment of a solid tumor necessitates the adaptation of these cells to ER stress. Hypoxia, in the context of the tumor microenvironment, is a critical ER stress that activates the unfolded protein response (UPR). This review focuses on the role of the IRE1-XBP1 branch of the UPR and its role in mediating cell survival and tumor growth. Inhibition of this pathway will be discussed as a therapeutic strategy.

引用

页码：756 / 759

页数：4

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