Effects of roxithromycin on the production of lipase and neutrophil chemotactic factor by Propionibacterium acnes

被引：13

作者：

Akamatsu, H

Tomita, T

Horio, T

机构：

[1] Fujita Hlth Univ, Sch Med, Dept Dermatol, Toyoake, Aichi 4701192, Japan

[2] ICAM Co Ltd, Tokyo, Japan

[3] Kansai Med Univ, Dept Dermatol, Osaka, Japan

来源：

DERMATOLOGY | 2002年 / 204卷 / 04期

关键词：

roxithromycin; Propionibacterium acnes; lipase; neutrophil chemotactic factor; acne;

D O I：

10.1159/000063358

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background: The macrolide antibiotic roxithromycin is effective against acne associated with inflammation, but the mechanism by which this is achieved has not been clarified. Objective:We studied the effects of roxithromycin on the production of lipase and neutrophil chemotactic factor by Propionibacterium acnes in vitro. Results: Roxithromycin significantly inhibited the production of lipase and neutrophil chemotactic factor by P. acnes at a concentration one eighth of the MIC, at which the growth curve of P. acnes is not affected. Conclusion: One mechanism of the effectiveness of roxithromycin in acne therapy is thought to be the inhibition of bacterial lipase and neutrophil chemotactic factor production by P. acnes. Copyright (C) 2002 S. Karger AG, Basel.

引用

页码：277 / 280

页数：4

共 15 条

[1] The effect of roxithromycin on the generation of reactive oxygen species in vitro [J].