Insulin-like growth factor-I and bone: lessons from mice and men

被引：41

作者：

Kawai, Masanobu ^{[1
]}

Rosen, Clifford J. ^{[1
]}

机构：

[1] Maine Med Ctr, Res Inst, Scarborough, ME 04074 USA

来源：

PEDIATRIC NEPHROLOGY | 2009年 / 24卷 / 07期

关键词：

Insulin-like growth factor-I; Skeletal acquisition; QUANTITATIVE TRAIT LOCI; GENE PROMOTER POLYMORPHISM; MINERAL DENSITY; POSTNATAL-GROWTH; TRANSGENIC MICE; OSTEOBLAST DIFFERENTIATION; OSTEOPOROTIC PATIENTS; BODY-COMPOSITION; ADULT PATIENTS; PPAR-GAMMA;

D O I：

10.1007/s00467-008-1040-6

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Studies of humans and animals have illustrated a strong association between insulin-like growth factor (IGF)-I and skeletal acquisition. However, the precise molecular and cellular mechanisms underlying this effect still largely remain unknown. Recent advances in molecular and genetic techniques for in vivo studies provide excellent tools for us to explore how circulating and skeletal insulin-like growth factor-I (IGF-I) may affect not only peak bone mass but also bone loss. This review highlights recent findings that shed new light on the interaction of the IGF-I signaling pathway with other skeletal networks, and the role of IGF-I in the bone marrow milieu.

引用

页码：1277 / 1285

页数：9

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