Chemistry, biological properties and SAR analysis of quinoxalinones

被引：245

作者：

Carta, A. ^{[1
]}

Piras, S. ^{[1
]}

Loriga, G. ^{[1
]}

Paglietti, G. ^{[1
]}

机构：

[1] Univ Sassari, Dipartimento Farmaco Chim Tossicol, Fac Pharm, I-07100 Sassari, Italy

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2006年 / 6卷 / 11期

关键词：

quinoxalin-2(3)-ones; quinoxalin-2,3-diones; AMPA antagonists; GlY(N) antagonists; antimicrobial activity; anti-cancer activity; Pgp antagonists; antiallergic activity; antithrombotic activity; SAR studies; chemical syntheses and reactions;

D O I：

10.2174/138955706778742713

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Quinoxaline derivatives have received much attention in recent years owing to their both biological properties and pharmaceutical applications. In this review we focus the attention on quinoxalin-2(3)-ones and quinoxalin-2,3-diones. These derivatives are particularly interesting since some of them showed antimicrobial (against several bacteria, viruses, fungi, etc), or anticancer activities. Furthermore, others are reported to be. potent no-NMDA glutamate receptor antagonists, endowed with anxiolytic, deconditioning, analgesic, antispastic, antiallergic, antithrombotic activities. In this article we also report SAR studies and the most important methods of synthesis of the quinoxalin-2(3)-(di)ones.

引用

页码：1179 / 1200

页数：22

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