Anti-ulcerogenic evaluation of the Persian tooth brush tree (Salvadora persica)

被引：4

作者：

Galati, EM ^{[1
]}

Germanò, MP ^{[1
]}

Rossitto, A ^{[1
]}

d'Aquino, A ^{[1
]}

Sanogo, R ^{[1
]}

机构：

[1] Univ Messina, Sch Pharm, Pharmacobiol Dept, I-98168 Messina, Italy

来源：

PHARMACEUTICAL BIOLOGY | 1999年 / 37卷 / 05期

关键词：

anti-ulcerogenic activity; Salvadora persica L; decoction; young twigs;

D O I：

10.1076/phbi.37.5.325.6055

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The effect of the lyophilized decoction of Salvadora persica on ulceration induced by ethanol, indomethacin and cold restraint stress was investigated in rats. Pre-treatment tests in rats revealed that the extract possessed significant protective action against ulcers induced by ethanol or stress. The protective effect was not altered by indomethacin, administered as a prostaglandin biosynthesis inhibitor. Salvadora persica shows some increase in gastric mucus with a certain diminution in the ulcer index in cold stress-induced ulcers. However, the drug failed to heal ethanol and indomethacin-induced ulcers.

引用

页码：325 / 328

页数：4

共 11 条

[1] EVALUATION OF MASTIC, A CRUDE DRUG OBTAINED FROM PISTACIA-LENTISCUS FOR GASTRIC AND DUODENAL ANTIULCER ACTIVITY [J].

ALSAID, MS ;

AGEEL, AM ;

PARMAR, NS ;

TARIQ, M .

JOURNAL OF ETHNOPHARMACOLOGY, 1986, 15 (03) :271-278

[2]

APARICIO L, 1977, ARCH INT PHARMACOD T, V227, P130

[3]

BULBENA O, 1986, Revista de Farmacologia Clinica y Experimental, V3, P105

[4] EVALUATION OF POTENTIAL OF GASTRIC ULCERATION AFTER ADMINISTRATION OF CERTAIN DRUGS [J].

CIOLI, V ;

SILVESTR.B ;

DORDONI, F .

EXPERIMENTAL AND MOLECULAR PATHOLOGY, 1967, 6 (01) :68-&

[5]

DELSOLDATO P, 1985, EUR J PHARMACOL, V106, P53

[6] SAUDI-ARABIAN MEDICINAL-PLANTS - SALVADORA-PERSICA [J].

EZMIRLY, ST ;

CHENG, JC ;

WILSON, SR .

PLANTA MEDICA, 1979, 35 (02) :191-192

[7]

FAROOQI M I H, 1968, Quarterly Journal of Crude Drug Research, V8, P1297

[8]

KERHARO J, 1974, PHARMACOPEE SENEGALA, P716

[9]

MAGISTRETTI MJ, 1988, ARZNEIMITTELFORSCH, V38-1, P686

[10]

SENAY EC, 1967, P SOC EXP BIOL MED, V124, P1221

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