Blood substitutes

被引：89

作者：

Winslow, RM ^{[1
]}

机构：

[1] Sangart Inc, San Diego, CA 92121 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2000年 / 40卷 / 03期

关键词：

blood substitutes; transfusion; surface-modified hemoglobin; intramolecular cross-linked hemoglobin; polymerized hemoglobin;

D O I：

10.1016/S0169-409X(99)00045-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Red cell substitutes are a group of oxygen carriers designed to temporarily replace transfused blood. Each product is unique in its limitations and advantages. Research and development has been slow because of the far-reaching consequences of replacing an oxygen carrier outside of the red cell. Nevertheless, a number of products are in advanced clinical trials and nearing the market. When they are available for use it is likely that development will accelerate and even better products will substantially alleviate the world-wide shortage of blood for transfusion and enable the delivery of medical care to underserved populations. An important consequence of the development of these products has been a better understanding of how oxygen is delivered to tissues. (C) 2000 Elsevier Science BN. All rights reserved.

引用

页码：131 / 142

页数：12

共 40 条

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