The Role of Intestinal Alkaline Phosphatase in Inflammatory Disorders of Gastrointestinal Tract

被引：129

作者：

Bilski, Jan ^{[1
]}

Mazur-Bialy, Agnieszka ^{[1
]}

Wojcik, Dagmara ^{[2
]}

Zahradnik-Bilska, Janina ^{[3
]}

Brzozowski, Bartosz ^{[3
]}

Magierowski, Marcin ^{[2
]}

Mach, Tomasz ^{[3
]}

Magierowska, Katarzyna ^{[2
]}

Brzozowski, Tomasz ^{[2
]}

机构：

[1] Jagiellonian Univ, Dept Ergon & Exercise Physiol, Fac Hlth Sci, Coll Med, Krakow, Poland

[2] Jagiellonian Univ, Coll Med, Fac Med, Dept Physiol, Krakow, Poland

[3] Jagiellonian Univ, Coll Med, Univ Hosp, Gastroenterol & Hepatol Clin, Krakow, Poland

来源：

MEDIATORS OF INFLAMMATION | 2017年 / 2017卷

关键词：

HIGH-FAT DIET; ACUTE KIDNEY INJURY; TOLL-LIKE RECEPTORS; GUT MICROBIOTA; BOWEL-DISEASE; TIGHT JUNCTION; METABOLIC SYNDROME; BARRIER FUNCTION; CYSTIC-FIBROSIS; INDUCED OBESITY;

D O I：

10.1155/2017/9074601

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Over the past fewyears, the role of intestinal alkaline phosphatase (IAP) as a crucialmucosal defence factor essential formaintaining gut homeostasis has been established. IAP is an important apical brush border enzyme expressed throughout the gastrointestinal tract and secreted both into the intestinal lumen and into the bloodstream. IAP exerts its effects through dephosphorylation of proinflammatory molecules including lipopolysaccharide (LPS), flagellin, and adenosine triphosphate (ATP) released from cells during stressful events. Diminished activity of IAP could increase the risk of disease through changes in the microbiome, intestinal inflammation, and intestinal permeability. Exogenous IAP exerts a protective effect against intestinal and systemic inflammation in a variety of diseases and represents a potential therapeutic agent in diseases driven by gut barrier dysfunction such as IBD. The intestinal protective mechanisms are impaired in IBD patients due to lower synthesis and activity of endogenous IAP, but the pathomechanism of this enzyme deficiency remains unclear. IAP has been safely administered to humans and the human recombinant form of IAP has been developed. This review was designed to provide an update in recent research on the involvement of IAP in intestinal inflammatory processes with focus on IBD in experimental animal models and human patients.

引用

页数：9

共 97 条

[1]

Intestinal Alkaline Phosphatase Prevents Antibiotic-Induced Susceptibility to Enteric Pathogens [J].