Radiation resistance and stem-like cells in brain tumors

被引：216

作者：

Hambardzumyan, Dolores ^{[1
]}

Squartro, Massimo ^{[1
]}

Holland, Eric C. ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Canc Biol & Genet, New York, NY 10021 USA

来源：

CANCER CELL | 2006年 / 10卷 / 06期

关键词：

D O I：

10.1016/j.ccr.2006.11.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The concepts of stem cells being resistant to therapy, stem-like cells existing in brain tumors, and these tumors initially responding to therapy followed by recurrence are well documented. On this foundation, a recent paper in Nature has demonstrated that CD133-expressing glioma cells in vivo and in culture are relatively resistant to radiation. The mechanism of resistance involves the cell-cycle-regulating proteins CHK1/CHK2. The data raise many questions about the details of radiobiology of stem-like cells in their native environment within tumors in vivo. These answers may lead to better optimization of radiation treatments and schedules for these patients.

引用

页码：454 / 456

页数：3

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