Synthesis of functional bisphosphonates via new palladium-catalyzed bis-hydrophosphorylation reactions

被引：50

作者：

Allen, A ^{[1
]}

Manke, DR ^{[1
]}

Lin, WB ^{[1
]}

机构：

[1] Brandeis Univ, Dept Chem, Waltham, MA 02454 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 02期

基金：

美国国家科学基金会;

关键词：

palladium catalysts; phosphorylation; alkynes;

D O I：

10.1016/S0040-4039(99)02042-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of functional bisphosphonates have been synthesized in good isolated yields via new palladium-catalyzed bis-hydrophosphorylation reactions of terminal alkynes and dialkyl phosphites. The scope and mechanism for such a bis-hydrophosphorylation process are also discussed. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：151 / 154

页数：4

共 8 条

[1] Unprecedented insertion of alkynes into a palladium-phosphine bond. A facile route to palladium-bound alkenyl phosphorus ylides [J].