Effects of blood pressure lowering and metabolic control on systolic left ventricular function in Type II diabetes mellitus

Decreased left ventricular long-axis function may be the earliest stage in subclinical heart failure in Type II diabetes. To assess whether a decrease in SBP (systolic blood pressure) or a change in metabolic control would improve the long-axis function, 48 Type II diabetic patients participating in the CALM II (Candesartan and Lisinopril Microalbuminuria II) study were included in the present study. Patients were examined with tissue Doppler echocardiography at baseline and after 3 and 12 months of follow-up. Corresponding blood pressure, fructosamine and HbAlc (glycated haemoglobin) values were obtained. During the follow-up period, a decrease in SBP of 8 mmHg was seen (from 141 +/- 11 mmHg at baseline to 133 +/- 12 mmHg; P < 0.001) and the peak systolic strain rate was significantly improved (from -1.10 +/- 0.25 at baseline to -1.25 +/- 0.22; P < 0.01). There was a highly significant relationship between the changes in systolic strain rate, HbA(lc) (P < 0.001) and fructosamine (P < 0.05), and similarly to changes in left ventricular mass (P < 0.05), whereas the correlation to the SBP reduction was not significant. Patients with improved glycaemic control, defined as a reduced HbA(lc) value after 12 months of follow-up, had a significantly improved strain rate (from -1.07 +/- 0.3 s(-1) at baseline to -1.32 + 0.25 s(-1); P < 0.01) compared with patients with increases in HbA(lc) (from -1.14 +/- 0.25 s(-1) at baseline to -1.16 +/- 0.27 s(-1); P = not significant). The two groups had comparable baseline values of SBP, left ventricular mass, age and disease duration. In conclusion, changes in left ventricular systolic long-axis function are significantly correlated with changes in left ventricular mass, as well as metabolic control, in hypertensive patients with Type II diabetes mellitus.