Choanal atresia associated with prenatal methimazole exposure: Three new patients

被引：30

作者：

Barbero, P

Ricagni, C

Mercado, G

Bronberg, R

Torrado, M

机构：

[1] Ctr Nacl Genet Med, RA-1725 Buenos Aires, DF, Argentina

[2] Hosp Garrahan, Serv Genet, Buenos Aires, DF, Argentina

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS PART A | 2004年 / 129A卷 / 01期

关键词：

methimazole; embryopathy; choanal atresia; teratology;

D O I：

10.1002/ajmg.a.20668

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We report three patients with bilateral choanal atresia in children prenatally exposed to methimazole (MMI) in order to define a MMI embryopathy clinical pattern. The combination of choanal atresia and other specific malformations strongly resembles previously reported patients exposed to MMI in utero. At present, propylthiouracil is considered the best treatment in pregnancies. However in Argentina and some other countries MMI is the only antithyroid drug, possibly posing a significant risk to the unborn fetus. (C) 2004 Wiley-Liss, Inc.

引用

收藏

页码：83 / 86

页数：4

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