Antimitotic diterpenes from Erythropodium caribaeorum test pharmacophore models for microtubule stabilization

被引：53

作者：

Cinel, B

Roberge, M

Behrisch, H

van Ofwegen, LP

Castro, CB

Andersen, RJ

机构：

[1] Univ British Columbia, Dept Chem EOS, Vancouver, BC V6T 1Z1, Canada

[2] Univ British Columbia, Dept Radiol EOS, Vancouver, BC V6T 1Z1, Canada

[3] Univ British Columbia, Dept Biochem & Mol Biol, Vancouver, BC V6T 1Z3, Canada

[4] Natl Museum Nat Hist, Leiden, Netherlands

[5] Museu Nacl, Rio De Janeiro, Brazil

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 03期

关键词：

D O I：

10.1021/ol9912027

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Six new antimitotic diterpenes, 2-7, have been isolated from the Caribbean octocoral Erythropodium caribaeorum, Structural variations encountered in this group of natural products test recently proposed pharmacophore models for microtubule stabilizing compounds.

引用

页码：257 / 260

页数：4

共 19 条

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[2] The coral-derived natural products eleutherobin and sarcodictyins A and B: Effects on the assembly of purified tubulin with and without microtubule-associated proteins and binding at the polymer taxoid site [J].