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Mitochondrial fusion and division: Regulation and role in cell viability

被引：132
作者：
Benard, Giovanni [1 ]
Karbowski, Mariusz [1 ]
机构：
[1] Univ Maryland, Inst Biotechnol, Ctr Med Biotechnol, Baltimore, MD 21201 USA
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2009年 / 20卷 / 03期
关键词：
Mitochondria; Fusion; Division; Large GTPase; Cell homeostasis; DOMINANT OPTIC ATROPHY; DYNAMIN-RELATED PROTEIN; CYTOCHROME-C RELEASE; M-AAA PROTEASE; OUTER-MEMBRANE; INNER MEMBRANE; BAX ACTIVATION; OPA1; FISSION; DRP1;
D O I：
10.1016/j.semcdb.2008.12.012
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Discovery of various molecular components regulating dynamics and organization of the mitochondria in cells, together with novel insights into the role of mitochondrial fusion and division in the maintenance of cellular homeostasis, have provided some of the most exciting breakthroughs in the last decade of mitochondrial research. The focus of this review is on the regulation of mitochondrial fusion and division machineries. The newly identified factors associated with mitofusin/OPA1-dependent mitochondrial fusion, and Drp1-dependent mitochondrial division are discussed. Furthermore, the most recent findings on the role of mitochondrial fusion and division in the maintenance of cell function are also reviewed here in some detail. (C) 2009 Elsevier Ltd. All rights reserved.
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页码：365 / 374
页数：10
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