Conformational analogues of Oxamflatin as histone deacetylase inhibitors

被引:20
作者
Dear, Anthony E.
Liu, Hong B.
Mayes, Penelope A.
Perlmutter, Patrick
机构
[1] Monash Univ, Sch Chem, Clayton, Vic 3800, Australia
[2] Monash Univ, Dept Med, Australian Ctr Blood Dis, Prahran, Vic 3181, Australia
关键词
D O I
10.1039/b608213k
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Conformational analogues of the hydroxamic acid Oxamflatin 1 - compounds 3a, 3b and 4 - have been synthesised to enable evaluation of the impact of varying the linking section on histone deacetylase inhibition. Preliminary testing indicates treatment of leukaemia cells with each of the analogues leads to significant inhibition of histone deacetylase and reduction in cell growth and proliferation.
引用
收藏
页码:3778 / 3784
页数:7
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