Family and twin studies in inflammatory bowel disease

被引：309

作者：

Halme, Leena

Paavola-Sakki, Paulina

Turunen, Ulla

Lappalainen, Maarit

Farkkila, Martti

Kontula, Kimmo

机构：

[1] Helsinki Univ Hosp, Dept Transplantat & Liver Surg, FIN-00029 Helsinki, Finland

[2] Helsinki Univ Hosp, Biomedicum Helsinki, Dept Med, Res Program Mol Med, FIN-00170 Helsinki, Finland

[3] Helsinki Univ Hosp, Dept Gastroenterol, FIN-00029 Helsinki, Finland

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2006年 / 12卷 / 23期

关键词：

D O I：

10.3748/wjg.v12.i23.3668

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Studies examining the inheritance of inflammatory bowel disease (IBD) within different family groups have been the basis for recent molecular advances in the genetics of IBD. The derived heritability in Crohn's disease (CD) is higher than in many other complex diseases. The risk of IBD is highest in first-degree relatives of a CD proband, but first-degree relatives of a proband suffering from ulcerative colitis (UC) and more distant relatives are also at increased risk. Disease concordance rates in IBD have been examined in multiplex families and in three large European twin studies. (c) 2006 The WJG Press. All rights reserved.

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页码：3668 / 3672

页数：5

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