Hardy-Weinberg testing for HLA class II (DRB1, DQA1, DQB1, AND DPB1) loci in 26 human ethnic groups

被引：35

作者：

Chen, JJ

Hollenbach, JA

Trachtenberg, EA

Just, JJ

Carrington, M

Ronningen, KS

Begovich, A

King, MC

McWeeney, S

Mack, SJ

Erlich, HA

Thomson, G

机构：

[1] St Louis Univ, Sch Publ Hlth, St Louis, MO 63108 USA

[2] Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA

[3] Childrens Hosp, Oakland Res Inst, Oakland, CA 94609 USA

[4] Millennium Pharmaceut Inc, Dept Human Genet, Cambridge, MA USA

[5] NCI, Frederick Canc Res & Dev Ctr, Frederick, MD USA

[6] Natl Inst Publ Hlth, Epidemiol Sect, Oslo, Norway

[7] Roche Mol Syst, Dept Human Genet, Alameda, CA USA

[8] Univ Washington, Dept Genet, Seattle, WA 98195 USA

[9] Univ Washington, Dept Med, Seattle, WA 98195 USA

来源：

TISSUE ANTIGENS | 1999年 / 54卷 / 06期

关键词：

exact test; Hardy-Weinberg proportions; HLA; individual test; population genetics;

D O I：

10.1034/j.1399-0039.1999.540601.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Testing the fit of population data to Hardy-Weinberg proportions is crucial in the validation of many current approaches in population genetic studies. In this paper, we tested fit to Hardy-Weinberg proportions using exact approaches for both the overall and individual heterozygote genotype data of four HLA Class II loci: DRB1, DQA1, DQB1, and DPB1, from 26 human populations. Eighty of 99 overall tests fit the Hardy-Weinberg expectation (73% for DRB1, 89% for DQA1, 81% for DQB1 and 81% for DPB1). Deviations from Hardy-Weinberg proportions were both locus and group specific. Although we could not rule out other mechanisms at work, the individual test results indicated that the departure was possibly partly due to recent admixture. Evidence for selection and other sources of deviation are also discussed.

引用

页码：533 / 542

页数：10

共 25 条

[1] HLA and HIV-1:: Heterozygote advantage and B*35-Cw*04 disadvantage [J].