Effect of Layer Thickness and Printing Orientation on Mechanical Properties and Dimensional Accuracy of 3D Printed Porous Samples for Bone Tissue Engineering

被引:209
作者
Farzadi, Arghavan [1 ]
Solati-Hashjin, Mehran [1 ,2 ]
Asadi-Eydivand, Mitra [1 ]
Abu Osman, Noor Azuan [1 ]
机构
[1] Univ Malaya, Dept Biomed Engn, Fac Engn, Kuala Lumpur, Malaysia
[2] Amirkabir Univ Technol, Biomat Ctr Excellence, Tehran, Iran
关键词
SOLID FREEFORM FABRICATION; CALCIUM-PHOSPHATE; 3-DIMENSIONAL SCAFFOLDS; HYDROXYAPATITE; PRINTABILITY; REGENERATION; SUBSTITUTES; CERAMICS; PURPOSES; POWDERS;
D O I
10.1371/journal.pone.0108252
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];
摘要
Powder-based inkjet 3D printing method is one of the most attractive solid free form techniques. It involves a sequential layering process through which 3D porous scaffolds can be directly produced from computer-generated models. 3D printed products' quality are controlled by the optimal build parameters. In this study, Calcium Sulfate based powders were used for porous scaffolds fabrication. The printed scaffolds of 0.8 mm pore size, with different layer thickness and printing orientation, were subjected to the depowdering step. The effects of four layer thicknesses and printing orientations, (parallel to X, Y and Z), on the physical and mechanical properties of printed scaffolds were investigated. It was observed that the compressive strength, toughness and Young's modulus of samples with 0.1125 and 0.125 mm layer thickness were more than others. Furthermore, the results of SEM and mu CT analyses showed that samples with 0.1125 mm layer thickness printed in X direction have more dimensional accuracy and significantly close to CAD software based designs with predefined pore size, porosity and pore interconnectivity.
引用
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页数:14
相关论文
共 41 条
[1]
3D printing of bone substitute implants using calcium phosphate and bioactive glasses [J].
Bergmann, Christian ;
Lindner, Markus ;
Zhang, Wen ;
Koczur, Karolina ;
Kirsten, Armin ;
Telle, Rainer ;
Fischer, Horst .
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY, 2010, 30 (12) :2563-2567
[2]
Computed tomography characterisation of additive manufacturing materials [J].
Bibb, Richard ;
Thompson, Darren ;
Winder, John .
MEDICAL ENGINEERING & PHYSICS, 2011, 33 (05) :590-596
[3]
A review of trends and limitations in hydrogel-rapid prototyping for tissue engineering [J].
Billiet, Thomas ;
Vandenhaute, Mieke ;
Schelfhout, Jorg ;
Van Vlierberghe, Sandra ;
Dubruel, Peter .
BIOMATERIALS, 2012, 33 (26) :6020-6041
[4]
Bone tissue engineering using 3D printing [J].
Bose, Susmita ;
Vahabzadeh, Sahar ;
Bandyopadhyay, Amit .
MATERIALS TODAY, 2013, 16 (12) :496-504
[5]
New depowdering-friendly designs for three-dimensional printing of calcium phosphate bone substitutes [J].
Butscher, A. ;
Bohner, M. ;
Doebelin, N. ;
Hofmann, S. ;
Mueller, R. .
ACTA BIOMATERIALIA, 2013, 9 (11) :9149-9158
[6]
Moisture based three-dimensional printing of calcium phosphate structures for scaffold engineering [J].
Butscher, A. ;
Bohner, M. ;
Doebelin, N. ;
Galea, L. ;
Loeffel, O. ;
Mueller, R. .
ACTA BIOMATERIALIA, 2013, 9 (02) :5369-5378
[7]
Structural and material approaches to bone tissue engineering in powder-based three-dimensional printing [J].
Butscher, A. ;
Bohner, M. ;
Hofmann, S. ;
Gauckler, L. ;
Mueller, R. .
ACTA BIOMATERIALIA, 2011, 7 (03) :907-920
[8]
Printability of calcium phosphate powders for three-dimensional printing of tissue engineering scaffolds [J].
Butscher, Andre ;
Bohner, Marc ;
Roth, Christian ;
Ernstberger, Annika ;
Heuberger, Roman ;
Doebelin, Nicola ;
von Rohr, Philipp Rudolf ;
Mueller, Ralph .
ACTA BIOMATERIALIA, 2012, 8 (01) :373-385
[9]
Direct 3D powder printing of biphasic calcium phosphate scaffolds for substitution of complex bone defects [J].
Castilho, Miguel ;
Moseke, Claus ;
Ewald, Andrea ;
Gbureck, Uwe ;
Groll, Juergen ;
Pires, Ines ;
Tessmar, Joerg ;
Vorndran, Elke .
BIOFABRICATION, 2014, 6 (01)
[10]
Fabrication of computationally designed scaffolds by low temperature 3D printing [J].
Castilho, Miguel ;
Dias, Marta ;
Gbureck, Uwe ;
Groll, Juergen ;
Fernandes, Paulo ;
Pires, Ines ;
Gouveia, Barbara ;
Rodrigues, Jorge ;
Vorndran, Elke .
BIOFABRICATION, 2013, 5 (03)