Anti-inflammatory effect of Diammonium Glycyrrhizinate in a rat model of ulcerative colitis

被引：67

作者：

Hao Yuan ^{[1
]}

Wan-Sheng Ji

Ke-Xiang Wu

Jian-Xin Jiao

Liang-Hua Sun

Yong-Tang Feng

机构：

[1] Weifang Med Coll, Dept Internal Med, Weifang 261042, Shandong Prov, Peoples R China

[2] Weifang Med Coll, Affiliated Hosp, Weifang 261031, Shandong Prov, Peoples R China

[3] Weifang Med Coll, Lab Mol Immunol, Weifang 261042, Shandong Prov, Peoples R China

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2006年 / 12卷 / 28期

关键词：

ulcerative colitis; Diammonium Glycyrrhizinate; mechanism;

D O I：

10.3748/wjg.v12.i28.4578

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

AIM: To explore the anti-inflammatory mechanism of Diammonium Glycyrrhizinate in a rat model of ulcerative colitis induced by acetic acid. METHODS: Spragur-Dawley female rats were divided into four groups: Diammonium Glycyrrhizinate group, dexamethasone group, acetic acid control and normal control group. Colonic inflammation was evaluated by disease activity index, gross morphologic damage, histological injury and colonic myeloperoxidase activity. Immunohistochemistry was used to detect the expression of NF-kappa B, TNF-alpha and ICAM-1 in colonic mucosa. RESULTS: Compared to the acetic acid control, both Diammonium Glycyrrhizinate and dexamethasone showed a significant anti-inflammatory effect (P < 0.01). The expression of NF-kappa B, TNF-alpha and ICAM-1 in colonic mucosa was significantly lower in the Diammonium Glycyrrhizinate group and dexamethasone group than in the acetic acid group. CONCLUSION: Diammonium Glycyrrhizinate could reduce inflammatory injury in a rat model of ulcerative colitis. This may occur via suppression of NF-kappa B, TNF-alpha and ICAM-1 in colonic mucosa. (C) 2006 The WJG Press. All rights reserved.

引用

页码：4578 / 4581

页数：4

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