Stereocontrol of 5-endo-trig cyclisations by hydroxyl groups:: a formal short synthesis of (+)-muscarine

被引：17

作者：

Knight, DW ^{[1
]}

Staples, ER ^{[1
]}

机构：

[1] Cardiff Univ, Dept Chem, Cardiff CF10 3TB, S Glam, Wales

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 38期

关键词：

D O I：

10.1016/S0040-4039(02)01518-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

5-endo-Trig iodocyclisation of the (Z)-ene-diol derivative 10 gives almost exclusively the hydroxy-tetrahydrofuran 11, a precursor of (+)-muscarine 1 in four simple steps. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：6771 / 6773

页数：3

共 16 条

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[7] Stereochemical features of iodocyclisations of 3-alkene-1,2-diols to β-hydroxytetrahydrofurans
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[J]. TETRAHEDRON LETTERS, 2000, 41 (22) : 4447 - 4451
[8] ORGANOSILANES AS RADICAL-BASED REDUCING AGENTS IN SYNTHESIS
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[10] THE STRUCTURE OF MUSCARINE
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