TOPALi: software for automatic identification of recombinant sequences within DNA multiple alignments

被引：384

作者：

Milne, I ^{[1
]}

Wright, F

Rowe, G

Marshall, DF

Husmeier, D

McGuire, G

机构：

[1] Scottish Crop Res Inst, Dundee DD2 5DA, Scotland

[2] Univ Dundee, Dundee DD1 4HN, Scotland

来源：

BIOINFORMATICS | 2004年 / 20卷 / 11期

基金：

英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1093/bioinformatics/bth155

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

TOPALi is a new Java graphical analysis application that allows the user to identify recombinant sequences within a DNA multiple alignment (either automatically or via manual investigation). TOPALi allows a choice of three statistical methods to predict the positions of breakpoints due to past recombination. The breakpoint predictions are then used to identify putative recombinant sequences and their relationships to other sequences. In addition to its sophisticated interface, TOPALi can import many sequence formats, estimate and display phylogenetic trees and allow interactive analysis and/or automatic HTML report generation.

引用

页码：1806 / 1807

页数：2

共 6 条

[1] PAL: an object-oriented programming library for molecular evolution and phylogenetics [J].