Association study of polymorphisms in N-methyl-D-aspartate receptor 2B subunits (GRIN2B) gene with Korean alcoholism

被引：33

作者：

Kim, Jin Hee

Park, Mira

Yang, So Young

Jeong, Bum Seok

Yoo, Hee Jeong

Kim, Jong-Woo

Chung, Joo-Ho

Kim, Soon Ae

机构：

[1] Eulji Univ, Sch Med, Dept Pharmacol, Taejon 301832, South Korea

[2] Seoul Natl Univ, Bundang Hosp, Dept Neuropsychiat, Seoul, South Korea

来源：

NEUROSCIENCE RESEARCH | 2006年 / 56卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

alcoholism; N-methyl-D-aspartate (NMDA) receptor 2B gene (NR2B; GRIN2B); polymorphism; haplotype; association;

D O I：

10.1016/j.neures.2006.06.013

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The N-methyl-D-aspartate (NMDA) receptor 2B gene (GRIN2B) was studied as a candidate gene of alcoholism. This study aimed to investigate the association between each of the three GRIN2B polymorphisms (rs1806201, rs1805247, and rs1805502) and alcoholism. This study included 206 alcoholic patients and 189 unrelated control subjects of Korean origin. Associations between genotype, allele, and haplotype frequencies of the polymorphisms and alcoholism were investigated. The genotype frequencies of rs1806201 and the haplotype analysis of SNPs in this study show significantly differences between the case and controls. These findings suggest new candidate SNPs in GRIN2B for studying the genetic susceptibility to alcoholism. (c) 2006 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

引用

页码：220 / 223

页数：4

共 16 条

[1] Glutamate-mediated transmission, alcohol, and alcoholism [J].