Neutrophil CD64: a diagnostic marker for infection and sepsis

被引：144

作者：

Hoffmann, Johannes J. M. L. ^{[1
]}

机构：

[1] Abbott GmbH & Co KG, Abbott Diagnost Div, D-65205 Wiesbaden, Germany

来源：

CLINICAL CHEMISTRY AND LABORATORY MEDICINE | 2009年 / 47卷 / 08期

关键词：

cluster of differentiation 64 (CD64); diagnostic tests; Fc gamma receptor (Fc gamma R); infection; neutrophils; sensitivity; sepsis; specificity; FC-GAMMA-RI; COLONY-STIMULATING FACTOR; CELL-SURFACE EXPRESSION; C-REACTIVE PROTEIN; POLYMORPHONUCLEAR LEUKOCYTES; BACTERIAL-INFECTION; G-CSF; PERIPHERAL-BLOOD; INTERFERON-GAMMA; CLINICAL UTILITY;

D O I：

10.1515/CCLM.2009.224

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Neutrophilic granulocytes express Fc gamma receptor (Fc gamma R) [cluster of differentiation 64 (CD64) antigen] only when they are activated. Neutrophil CD64, demonstrated using flow cytometry, can be used as a diagnostic marker of infection and sepsis. Neutrophil CD64 is superior to C-reactive protein and hematological determinations for detecting systemic infection or sepsis, since it combines high sensitivity (90% or more) with high specificity (90%-100%) in both adults and children. In addition, the test performs well in distinguishing infection from flares in autoimmune inflammatory diseases and has somewhat more limited utility for differentiating bacterial from viral infection. This review summarizes the available literature regarding CD64 as a marker of infection, and outlines future clinical studies for confirming the diagnostic performance of this promising marker. Clin Chem Lab Med 2009;47:903-16.

引用

页码：903 / 916

页数：14

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