Inhibition of matrix metalloproteinases: An examination of the S1' pocket

被引：28

作者：

Miller, A

Askew, M

Beckett, RP

Bellamy, CL

Bone, EA

Coates, RE

Davidson, AH

Drummond, AH

Huxley, P

Martin, FM

Saroglou, L

Thompson, AJ

vanDijk, SE

Whittaker, M

机构：

[1] British Biotech Pharmaceuticals Ltd., Oxford OX4 5LY, Watlington Rd.

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(96)00602-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Peptidomimetic carboxylate- and hydroxamate-based inhibitors of matrix metalloproteinases containing extended P1' groups have been prepared. Potent inhibition and good selectivity for MMP-2 has been observed for the compounds produced. (C) 1997, Elsevier Science Ltd.

引用

页码：193 / 198

页数：6

共 27 条

[1] STROMELYSIN-1 - 3-DIMENSIONAL STRUCTURE OF THE INHIBITED CATALYTIC DOMAIN AND OF THE C-TRUNCATED PROENZYME
BECKER, JW
MARCY, AI
ROKOSZ, LL
AXEL, MG
BURBAUM, JJ
FITZGERALD, PMD
CAMERON, PM
ESSER, CK
HAGMANN, WK
HERMES, JD
SPRINGER, JP
[J]. PROTEIN SCIENCE, 1995, 4 (10) : 1966 - 1976
[2] BECKETT RP, 1993, SYNLETT, P137
[3] Recent advances in matrix metalloproteinase inhibitor research
Beckett, RP
Davidson, AH
Drummond, AH
Huxley, P
Whittaker, M
[J]. DRUG DISCOVERY TODAY, 1996, 1 (01) : 16 - 26
[4] MATRIX METALLOPROTEINASES - A REVIEW
BIRKEDALHANSEN, H
MOORE, WGI
BODDEN, MK
WINDSOR, LJ
BIRKEDALHANSEN, B
DECARLO, A
ENGLER, JA
[J]. CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE, 1993, 4 (02) : 197 - 250
[5] THE X-RAY CRYSTAL-STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN NEUTROPHIL COLLAGENASE INHIBITED BY A SUBSTRATE-ANALOG REVEALS THE ESSENTIALS FOR CATALYSIS AND SPECIFICITY
BODE, W
REINEMER, P
HUBER, R
KLEINE, T
SCHNIERER, S
TSCHESCHE, H
[J]. EMBO JOURNAL, 1994, 13 (06) : 1263 - 1269
[6] BONE EA, UNPUB
[7] STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN FIBROBLAST COLLAGENASE COMPLEXED WITH AN INHIBITOR
BORKAKOTI, N
WINKLER, FK
WILLIAMS, DH
DARCY, A
BROADHURST, MJ
BROWN, PA
JOHNSON, WH
MURRAY, EJ
[J]. NATURE STRUCTURAL BIOLOGY, 1994, 1 (02): : 106 - 110
[8] BROADHURST MJ, 1995, Patent No. 575844
[9] MATRILYSIN-INHIBITOR COMPLEXES - COMMON THEMES AMONG METALLOPROTEASES
BROWNER, MF
SMITH, WW
CASTELHANO, AL
[J]. BIOCHEMISTRY, 1995, 34 (20) : 6602 - 6610
[10] NOVEL INDOLACTAM-BASED INHIBITORS OF MATRIX METALLOPROTEINASES
CASTELHANO, AL
BILLEDEAU, R
DEWDNEY, N
DONNELLY, S
HORNE, S
KURZ, LJ
LIAK, TJ
MARTIN, R
UPPINGTON, R
YUAN, ZY
KRANTZ, A
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (13) : 1415 - 1420

← 1 2 3 →