Involvement of delta- and mu-opioid receptors in the potentiation of brain-stimulation reward

被引：27

作者：

Duvauchelle, CL ^{[1
]}

Fleming, SM ^{[1
]}

Kornetsky, C ^{[1
]}

机构：

[1] BOSTON UNIV,SCH MED,LAB BEHAV PHARMACOL,BOSTON,MA 02118

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1996年 / 316卷 / 2-3期

关键词：

DAMGO ([D-Ala(2)-MePhe(4)-Gly(ol)(5)]enkephalin); DPDPE; ([D-Pen(2); D-Pen(5)]enkephalin); opioids; opioid receptor antagonist; naltrindole;

D O I：

10.1016/S0014-2999(96)00674-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A rate-free method of determining brain-stimulation reward thresholds was used to identify the rewarding effects of the delta-opioid receptor and mu-opioid receptor agonist peptides, [D-Pen(2), D-Pen(5)]enkephalin (DPDPE) and [D-Ala(2)-MePhe(4)-Gly(ol)(5)]enkephalin (DAMGO). The nucleus accumbens-delivered opioid receptor agonists produced marked lowering of the threshold for ventral tegmental area brain-stimulation reward. No change in baseline thresholds was seen after peripheral administration of the nonpeptide delta-opioid receptor antagonist, naltrindole. However, an unexpected finding was that naltrindole blocked the threshold-lowering effects of both DPDPE and DAMGO. These data demonstrate nucleus accumbens activation of delta- and mu-opioid receptors and ventral tegmental area brain-stimulation reward share common brain substrates. In addition, the interference of both delta- and mu-opioid receptor mediated reward by naltrindole may have implications for therapeutic use.

引用

页码：137 / 143

页数：7

共 25 条

[1]

BALSKUBIK R, 1993, J PHARMACOL EXP THER, V264, P489

[2] INVOLVEMENT OF CENTRAL MU-OPIOID AND DELTA-OPIOID RECEPTORS IN MEDIATING THE REINFORCING EFFECTS OF BETA-ENDORPHIN IN THE RAT [J].

BALSKUBIK, R ;

SHIPPENBERG, TS ;

HERZ, A .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 175 (01) :63-69

[3] DELTA-OPIOID ANTAGONIST, NALTRINDOLE, SELECTIVELY BLOCKS ANALGESIA INDUCED BY DPDPE BUT NOT DAGO OR MORPHINE [J].

CALCAGNETTI, DJ ;

HOLTZMAN, SG .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1991, 38 (01) :185-190

[4] COMPARISON OF THE BEHAVIORAL-EFFECTS INDUCED BY ADMINISTRATION IN RAT NUCLEUS ACCUMBENS OR NUCLEUS CAUDATUS OF SELECTIVE MU AND DELTA OPIOID-PEPTIDES OR KELATORPHAN AN INHIBITOR OF ENKEPHALIN-DEGRADING-ENZYMES [J].

DAUGE, V ;

ROSSIGNOL, P ;

ROQUES, BP .

PSYCHOPHARMACOLOGY, 1988, 96 (03) :343-352

[5] KELATORPHAN, A POTENT ENKEPHALINASES INHIBITOR, AND OPIOID RECEPTOR AGONISTS DAGO AND DTLET, DIFFERENTIALLY MODULATE SELF-STIMULATION BEHAVIOR DEPENDING ON THE SITE OF ADMINISTRATION [J].

DEWITTE, P ;

HEIDBREDER, C ;

ROQUES, BP .

NEUROPHARMACOLOGY, 1989, 28 (07) :667-676

[6]

DROWER EJ, 1991, J PHARMACOL EXP THER, V259, P725

[7] MORPHINE LOWERING OF SELF-STIMULATION THRESHOLDS - LACK OF TOLERANCE WITH LONG-TERM ADMINISTRATION [J].

ESPOSITO, R ;

KORNETSKY, C .

SCIENCE, 1977, 195 (4274) :189-191

[8] SELF-ADMINISTRATION OF METHIONINE ENKEPHALIN INTO THE NUCLEUS ACCUMBENS [J].

GOEDERS, NE ;

LANE, JD ;

SMITH, JE .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1984, 20 (03) :451-455

[9] OPIOID RECEPTOR SUBTYPES ASSOCIATED WITH VENTRAL TEGMENTAL FACILITATION OF LATERAL HYPOTHALAMIC BRAIN-STIMULATION REWARD [J].

JENCK, F ;

GRATTON, A ;

WISE, RA .

BRAIN RESEARCH, 1987, 423 (1-2) :34-38

[10] REGIONAL REWARD DIFFERENCES WITHIN THE VENTRAL PALLIDUM ARE REVEALED BY MICROINJECTIONS OF A MU-OPIATE RECEPTOR AGONIST [J].

JOHNSON, PI ;

STELLAR, JR ;

PAUL, AD .

NEUROPHARMACOLOGY, 1993, 32 (12) :1305-1314

← 1 2 3 →