Gene regulation - Selfish elements make a mark

被引：5

作者：

Bushman, F ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Dept Microbiol, Philadelphia, PA 19104 USA

来源：

NATURE | 2004年 / 429卷 / 6989期

关键词：

D O I：

10.1038/429253b

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Transposons qualify as ‘selfish’ DNA elements, adding new copies of themselves into our genomes without regard for the consequences. This wilful habit may, however, help in normal gene regulation.

引用

页码：253 / 255

页数：3

共 8 条

[1] L1 (LINE-1) retrotransposon evolution and amplification in recent human history [J].

Boissinot, S ;

Chevret, P ;

Furano, AV .

MOLECULAR BIOLOGY AND EVOLUTION, 2000, 17 (06) :915-928

[2] A highly active synthetic mammalian retrotransposon [J].

Han, JS ;

Boeke, JD .

NATURE, 2004, 429 (6989) :314-318

[3] Transcriptional disruption by the L1 retrotransposon and implications for mammalian transcriptomes [J].

Han, JS ;

Szak, ST ;

Boeke, JD .

NATURE, 2004, 429 (6989) :268-274

[4] Mobile elements: Drivers of genome evolution [J].

Kazazian, HH .

SCIENCE, 2004, 303 (5664) :1626-1632

[5] Survival strategies for transposons and genomes [J].

Sandra L Martin ;

David J Garfinkel .

Genome Biology, 4 (4)

[6] SELFISH DNA - THE ULTIMATE PARASITE [J].

ORGEL, LE ;

CRICK, FHC .

NATURE, 1980, 284 (5757) :604-607

[7] A mouse model of human L1 retrotransposition [J].

Ostertag, EM ;

DeBerardinis, RJ ;

Goodier, JL ;

Zhang, Y ;

Yang, N ;

Gerton, GL ;

Kazazian, HH .

NATURE GENETICS, 2002, 32 (04) :655-660

[8] RNA truncation by premature polyadenylation attenuates human mobile element activity [J].

Perepelitsa-Belancio, V ;

Deininger, P .

NATURE GENETICS, 2003, 35 (04) :363-366

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