Novel fast-setting calcium silicate bone cements with high bioactivity and enhanced osteogenesis in vitro

被引：103

作者：

Ding, Shinn-Jyh ^{[1
]}

Shie, Ming-You ^{[2
]}

Wang, Chuan-Yeh ^{[1
]}

机构：

[1] Chung Shan Med Univ, Inst Oral Biol & Biomat Sci, Taichung 402, Taiwan

[2] Natl Cheng Kung Univ, Inst Biomed Engn, Tainan 701, Taiwan

来源：

JOURNAL OF MATERIALS CHEMISTRY | 2009年 / 19卷 / 08期

关键词：

PHOSPHATE CEMENT; SUBSTITUTED HYDROXYAPATITE; GLASSES; BEHAVIOR; SCAFFOLD; SYSTEM;

D O I：

10.1039/b819033j

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070305 [高分子化学与物理];

摘要：

Novel calcium silicate cements (CSCs) consisting of sol-gel-derived calcium silicate powder as a solid phase and ammonium phosphate solution as a liquid phase were developed. The diametral tensile strength, morphology, and phase composition of various cements were evaluated before and after immersion in physiological solution, in addition to setting time. The proliferation and osteogenetic expression of human osteosarcoma cell line U2OS for the cement specimens were also analyzed. The results indicated that the simultaneous formation of apatite and calcium silicate hydrates (CaO-SiO(2)-H(2)O, C-S-H) may endow CSCs with unique properties after mixing with a phosphate buffer solution. These CSCs were not only fast-setting within 9 min, as well as highly bioactive, but they also enhanced proliferation and differentiation of U2OS cells. The development of fast-setting CSCs with high bioactivity may thus have numerous applications as biomaterials.

引用

页码：1183 / 1190

页数：8

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