The steroid receptor RNA activator is the first functional RNA encoding a protein

被引：116

作者：

Chooniedass-Kothari, S ^{[1
]}

Emberley, E ^{[1
]}

Hamedani, MK ^{[1
]}

Troup, S ^{[1
]}

Wang, X ^{[1
]}

Czosnek, A ^{[1
]}

Hube, F ^{[1
]}

Mutawe, M ^{[1
]}

Watson, PH ^{[1
]}

Leygue, E ^{[1
]}

机构：

[1] Univ Manitoba, Fac Med, Dept Biochem & Med Genet, Winnipeg, MB R3E 0W3, Canada

来源：

FEBS LETTERS | 2004年 / 566卷 / 1-3期

关键词：

steroid receptor RNA activator; non-coding RNA; RNA interference; steroid receptor RNA activator homologue; steroid receptor RNA activator protein;

D O I：

10.1016/j.febslet.2004.03.104

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The steroid receptor RNA activator (SRA) has previously been characterized as belonging to the growing family of functional non-coding RNAs. However, we recently reported the Western blot detection of a putative endogenous SRA protein (SRAP) in breast cancer cells. Herein, we successfully suppressed the expression of this protein through specific RNA interference assay, unequivocally confirming its existence. Moreover, using database searches and Western blot analysis, we also showed that SRAP is highly conserved among chordata. Overall, our results suggest that SRA is the first example of a new class of functional RNAs also able to encode a protein. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：43 / 47

页数：5

共 12 条

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