Histone-deacetylase inhibitors: Novel drugs for the treatment of cancer

被引：1319

作者：

Johnstone, RW ^{[1
]}

机构：

[1] Peter MacCallum Canc Inst, Canc Immunol Program, Trescowthick Res Labs, Melbourne, Vic 3002, Australia

来源：

NATURE REVIEWS DRUG DISCOVERY | 2002年 / 1卷 / 04期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1038/nrd772

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The opposing actions of histone acetyltransferases (HATs) and histone deacetylases (HDACs) allow gene expression to be exquisitely regulated through chromatin remodelling. Aberrant transcription due to altered expression or mutation of genes that encode HATs, HDACs or their binding partners, is a key event in the onset and progression of cancer. HDAC inhibitors can reactivate gene expression and inhibit the growth and survival of tumour cells. The remarkable tumour specificity of these compounds, and their potency in vitro and in vivo, underscore the potential of HDAC inhibitors as exciting new agents for the treatment of cancer.

引用

页码：287 / 299

页数：13

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