The mRNA cap-binding protein eIF4E in post-transcriptional gene expression

被引：185

作者：

von der Haar, T

Gross, JD

Wagner, G

McCarthy, JEG

机构：

[1] Univ Manchester, Inst Sci & Technol, Dept Biomol Sci, Post Transcript Control Grp, Manchester M60 1QD, Lancs, England

[2] Univ Massachusetts, Sch Med, Dept Mol Pharmacol & Biochem, Worcester, MA 01605 USA

[3] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2004年 / 11卷 / 06期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1038/nsmb779

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Eukaryotic initiation factor 4E (eIF4E) has central roles in the control of several aspects of post-transcriptional gene expression and thereby affects developmental processes. It is also implicated in human diseases. This review explores the relationship between structural, biochemical and biophysical aspects of eIF4E and its function in vivo, including both long-established roles in translation and newly emerging ones in nuclear export and mRNA decay pathways.

引用

页码：503 / 511

页数：9

共 83 条

[1] A novel inhibitor of cap-dependent translation initiation in yeast: P20 competes with eIF4G for binding to eIF4E [J].

Altmann, M ;

Schmitz, N ;

Berset, C ;

Trachsel, H .

EMBO JOURNAL, 1997, 16 (05) :1114-1121

[2] RNA-binding activity of translation initiation factor eIF4G1 from Saccharomyces cerevisiae [J].

Berset, C ;

Zurbriggen, A ;

Djafarzadeh, S ;

Altmann, M ;

Trachsel, H .

RNA, 2003, 9 (07) :871-880

[3] Stopped-flow and Brownian dynamics studies of electrostatic effects in the kinetics of binding of 7-methyl-GpppG to the protein eIF4E [J].

Blachut-Okrasinska, E ;

Bojarska, E ;

Niedzwiecka, A ;

Chlebicka, L ;

Darzynkiewicz, E ;

Stolarski, R ;

Stepinski, J ;

Antosiewicz, JM .

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 2000, 29 (07) :487-498

[4] Biochemical characterisation of cap-poly(A) synergy in rabbit reticulocyte lysates:: the eIF4G-PABP interaction increases the functional affinity of eIF4E for the capped mRNA 5′-end [J].

Borman, AM ;

Michel, YM ;

Kean, KM .

NUCLEIC ACIDS RESEARCH, 2000, 28 (21) :4068-4075

[5] Dissolution of the maskin-eIF4E complex by cytoplasmic polyadenylation and poly(A)-binding protein controls cyclin B1 mRNA translation and oocyte maturation [J].

Cao, QP ;

Richter, JD .

EMBO JOURNAL, 2002, 21 (14) :3852-3862

[6] MULTIPLE FUNCTIONS FOR POLY(A)-BINDING PROTEIN IN MESSENGER-RNA DECAPPING AND DEADENYLATION IN YEAST [J].

CAPONIGRO, G ;

PARKER, R .

GENES & DEVELOPMENT, 1995, 9 (19) :2421-2432

[7] BINDING OF PROTEIN-SYNTHESIS INITIATION FACTOR-4E TO OLIGORIBONUCLEOTIDES - EFFECTS OF CAP ACCESSIBILITY AND SECONDARY STRUCTURE [J].

CARBERRY, SE ;

FRIEDLAND, DE ;

RHOADS, RE ;

GOSS, DJ .

BIOCHEMISTRY, 1992, 31 (05) :1427-1432

[8] Translational regulation in cell stress and apoptosis. Roles of the eIF4E binding proteins [J].

Clemens, MJ .

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2001, 5 (03) :221-239

[9] PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA [J].

Cohen, N ;

Sharma, M ;

Kentsis, A ;

Perez, JM ;

Strudwick, S ;

Borden, KLB .

EMBO JOURNAL, 2001, 20 (16) :4547-4559

[10] mRNA stabilization by poly(A) binding protein is independent of poly(A) and requires translation [J].

Coller, JM ;

Gray, NK ;

Wickens, MP .

GENES & DEVELOPMENT, 1998, 12 (20) :3226-3235

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