Triplet repeat polymorphism in the transmembrane region of the MICA gene in celiac disease

被引：20

作者：

Fernandez, L

Fernandez-Arquero, M

Gual, L

Lazaro, F

Maluenda, C

Polanco, I

Figueredo, MA

De la Concha, EG ^{[1
]}

机构：

[1] Univ Madrid, Hosp San Carlos, Dept Immunol, Madrid 28040, Spain

[2] Univ Madrid, Hosp San Carlos, Dept Pediat, Madrid 28040, Spain

[3] Hosp La Paz, Dept Pediat Gastroenterol, Madrid 28046, Spain

来源：

TISSUE ANTIGENS | 2002年 / 59卷 / 03期

关键词：

celiac disease; gene association; HLA; MICA;

D O I：

10.1034/j.1399-0039.2002.590307.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Celiac disease (CD) is characterized by a striking expansion of gammadeltaT cells in the intestine, These cells interact with MICA, a cell surface protein encoded by a major histocompatibility complex gene. We investigated whether MICA gene polymorphism could contribute to susceptibility to CD. DNA typing for HLA-DR, DQA1, DQB1, TNF-308, TNFa, TNFb and a triplet repeat polymorphism in the transmembrane region of the MICA gene were carried out. We performed case-control stratified association studies and transmission disequilibrium tests. Our results indicate that although there is no primary association between MICA polymorphism and CD, there is, in addition to HLA-DQ, a second susceptibility locus on the 8.1 ancestral haplotype in strong linkage disequilibrium with MICA A5.1 allele.

引用

页码：219 / 222

页数：4

共 19 条

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