Glioblastoma causing granulocytosis by secretion of granulocyte-colony-stimulating factor

被引：18

作者：

Hintzen, RQ

Voormolen, J

Sonneveld, P

van Duinen, SG

机构：

[1] Acad Hosp Rotterdam, Dept Hematol, NL-3000 CA Rotterdam, Netherlands

[2] Leiden Univ, Med Ctr, Dept Neurol, Leiden, Netherlands

[3] Leiden Univ, Med Ctr, Dept Neurosurg, Leiden, Netherlands

[4] Leiden Univ, Med Ctr, Dept Pathol, Leiden, Netherlands

来源：

NEUROLOGY | 2000年 / 54卷 / 01期

关键词：

glioblastoma multiforme; GBM; granulocyte colony-stimulating factor; G-CSF; neutrophilia; leukocytosis;

D O I：

10.1212/WNL.54.1.259

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We describe a patient with a glioblastoma multiforme with excessive granulocytosis in the peripheral blood. Shown at both protein and mRNA levels, the tumor produced very high levels of granulocyte-colony-stimulating factor (G-CSF). G-CSF is a growth factor that induces the recruitment of granulocytes. The paraneoplastic phenomenon described here partly mimicked a brain abscess. Production of G-CSF by (brain) tumor cells might be related to the granulocytosis common in malignant disease.

引用

页码：259 / 261

页数：3

共 9 条

[1] INTRACRANIAL ABSCESS COMPLICATING DIVERTICULITIS WITH CT SCAN MIMICKING PRIMARY GLIOMA [J].