Design and synthesis of highly potent fumagillin analogues from homology modeling for a human MetAP-2

被引：60

作者：

Han, CK

Ahn, SK

Choi, NS

Hong, RK

Moon, SK

Chun, HS

Lee, SJ

Kim, JW

Hong, CI

Kim, D

Yoon, JH

No, KT

机构：

[1] Chong Kun Dang Res Inst, Cheon An 330830, Chungcheongnamd, South Korea

[2] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

[3] Soong Sil Univ, CAMD Res Ctr, Seoul 156743, South Korea

[4] Soong Sil Univ, Dept Chem, Seoul 156743, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 01期

关键词：

antitumor compounds; molecular modeling/mechanics;

D O I：

10.1016/S0960-894X(99)00577-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

New fumagillin analogues were designed through structure-based molecular modeling with a human methionine aminopeptidase-2. Among the fumagillin analogues, cinnamic acid eater derivative CKD-731 showed 1000-fold more potent proliferation inhibitory activity on endothelial cell than TNP-470. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：39 / 43

页数：5

共 14 条

[1] EUKARYOTIC METHIONYL AMINOPEPTIDASES - 2 CLASSES OF COBALT-DEPENDENT ENZYMES [J].