Different roles of the IGF-I Ec peptide (MGF) and mature IGF-I in myoblast proliferation and differentiation

被引：246

作者：

Yang, SY ^{[1
]}

Goldspink, GE ^{[1
]}

机构：

[1] UCL, Royal Free & Univ Coll Med Sch, Dept Surg, Mol Tissue Repair Unit, London NW3 2PF, England

来源：

FEBS LETTERS | 2002年 / 522卷 / 1-3期

基金：

英国惠康基金;

关键词：

insulin-like growth factor-I splice variant; muscle differentiation; proliferation; C2C12; myoblast;

D O I：

10.1016/S0014-5793(02)02918-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The physiological function of a recently cloned splice variant of insulin-like growth factor-I (IGF-I; mechano growth factor (MGF)) was studied using an in vitro cell model. Unlike mature IGF-I, the distinct E domain of MGF inhibits terminal differentiation whilst increasing myoblast proliferation. Blocking the IGF-I receptor with a specific antibody indicated that the function of MGF E domain is mediated via a different receptor. The results provide a basis for localized tissue adaptation and helps explain why loss of muscle mass occurs in the elderly and in dystrophic muscle in which MGF production is markedly affected. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：156 / 160

页数：5

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