Brain evolution and uniqueness in the human genome

被引：15

作者：

Amadio, Jordan P.

Walsh, Christopher A. ^{[1
]}

机构：

[1] Childrens Hosp, Howard Hughes Med Inst, Beth Israel Deaconess Med Ctr, Div Genet, Boston, MA 02115 USA

[2] MIT, Broad Inst, Boston, MA 02115 USA

[3] Harvard Univ, Boston, MA 02115 USA

[4] Harvard Mit Div Hlth Sci & Technol, Boston, MA 02115 USA

来源：

CELL | 2006年 / 126卷 / 06期

关键词：

D O I：

10.1016/j.cell.2006.09.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Despite an ever-expanding database of sequenced mammalian genomes to be mined for clues, the emergence of the unique human brain remains an evolutionary enigma. In their new study, Pollard et al. (2006) trawl the human genome and those of other mammals in search of short conserved DNA elements that show extremely rapid evolution only in humans. As they report in a recent issue of Nature, their scan yielded a gene for a novel noncoding RNA that adopts a human-specific structure and may regulate neurodevelopment.

引用

页码：1033 / 1035

页数：3

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