New series of potent, orally bioavailable, non-peptidic cyclic sulfones as HIV-1 protease inhibitors

被引：64

作者：

Kim, CU ^{[1
]}

McGee, LR ^{[1
]}

Krawczyk, SH ^{[1
]}

Harwood, E ^{[1
]}

Harada, Y ^{[1
]}

Swaminathan, S ^{[1
]}

Bischofberger, N ^{[1
]}

Chen, MS ^{[1
]}

Cherrington, JM ^{[1
]}

Xiong, SF ^{[1
]}

Griffin, L ^{[1
]}

Cundy, KC ^{[1
]}

Lee, A ^{[1
]}

Yu, B ^{[1
]}

Gulnik, S ^{[1
]}

Erickson, JW ^{[1
]}

机构：

[1] NCI,FREDERICK CANC RES & DEV CTR,STRUCT BIOCHEM PROGRAM,SAIC FREDERICK,FREDERICK,MD 21702

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1996年 / 39卷 / 18期

关键词：

D O I：

10.1021/jm960340o

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：3431 / 3434

页数：4

共 14 条

[1] IN-VIVO EMERGENCE OF HIV-1 VARIANTS RESISTANT TO MULTIPLE PROTEASE INHIBITORS [J].

CONDRA, JH ;

SCHLEIF, WA ;

BLAHY, OM ;

GABRYELSKI, LJ ;

GRAHAM, DJ ;

QUINTERO, JC ;

RHODES, A ;

ROBBINS, HL ;

ROTH, E ;

SHIVAPRAKASH, M ;

TITUS, D ;

YANG, T ;

TEPPLER, H ;

SQUIRES, KE ;

DEUTSCH, PJ ;

EMINI, EA .

NATURE, 1995, 374 (6522) :569-571

[2]

Erickson John W., 1993, Perspectives in Drug Discovery and Design, V1, P109, DOI 10.1007/BF02171658

[3] K65R MUTATION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REVERSE-TRANSCRIPTASE ENCODES CROSS-RESISTANCE TO 9-(2-PHOSPHONYLMETHOXYETHYL)ADENINE [J].

GU, ZX ;

SALOMON, H ;

CHERRINGTON, JM ;

MULATO, AS ;

CHEN, MS ;

YARCHOAN, R ;

FOLI, A ;

SOGOCIO, KM ;

WAINBERG, MA .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (08) :1888-1891

[4] PRESENT STATUS AND FUTURE-PROSPECTS FOR HIV THERAPIES [J].

JOHNSTON, MI ;

HOTH, DF .

SCIENCE, 1993, 260 (5112) :1286-1293

[5] ABT-538 IS A POTENT INHIBITOR OF HUMAN-IMMUNODEFICIENCY-VIRUS PROTEASE AND HAS HIGH ORAL BIOAVAILABILITY IN HUMANS [J].

KEMPF, DJ ;

MARSH, KC ;

DENISSEN, JF ;

MCDONALD, E ;

VASAVANONDA, S ;

FLENTGE, CA ;

GREEN, BE ;

FINO, L ;

PARK, CH ;

KONG, XP ;

WIDEBURG, NE ;

SALDIVAR, A ;

RUIZ, L ;

KATI, WM ;

SHAM, HL ;

ROBINS, T ;

STEWART, KD ;

HSU, A ;

PLATTNER, JJ ;

LEONARD, JM ;

NORBECK, DW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (07) :2484-2488

[6] CRYSTAL-STRUCTURE OF HIV-1 PROTEASE IN COMPLEX WITH VX-478, A POTENT AND ORALLY BIOAVAILABLE INHIBITOR OF THE ENZYME [J].

KIM, EE ;

BAKER, CT ;

DWYER, MD ;

MURCKO, MA ;

RAO, BG ;

TUNG, RD ;

NAVIA, MA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (03) :1181-1182

[7] 1,6-ANHYDRO-1(6)-THIO-L-IDITOL AND D-MANNITOL, AND SOME DERIVATIVES THEREOF [J].

KUSZMANN, J ;

SOHAR, P .

CARBOHYDRATE RESEARCH, 1977, 56 (01) :105-115

[8] RATIONAL DESIGN OF POTENT, BIOAVAILABLE, NONPEPTIDE CYCLIC UREAS AS HIV PROTEASE INHIBITORS [J].

LAM, PYS ;

JADHAV, PK ;

EYERMANN, CJ ;

HODGE, CN ;

RU, Y ;

BACHELER, LT ;

MEEK, JL ;

OTTO, MJ ;

RAYNER, MM ;

WONG, YN ;

CHANG, CH ;

WEBER, PC ;

JACKSON, DA ;

SHARPE, TR ;

ERICKSONVIITANEN, S .

SCIENCE, 1994, 263 (5145) :380-384

[9]

LEE AM, UNPUB

[10] NOVEL FLUOROGENIC SUBSTRATES FOR ASSAYING RETROVIRAL PROTEASES BY RESONANCE ENERGY-TRANSFER [J].

MATAYOSHI, ED ;

WANG, GT ;

KRAFFT, GA ;

ERICKSON, J .

SCIENCE, 1990, 247 (4945) :954-958

← 1 2 →