ANCHOR: web server for predicting protein binding regions in disordered proteins

被引：460

作者：

Dosztanyi, Zsuzsanna ^{[1
]}

Meszaros, Balint ^{[1
]}

Simon, Istvan ^{[1
]}

机构：

[1] Hungarian Acad Sci, Inst Enzymol, Biol Res Ctr, H-1518 Budapest, Hungary

来源：

BIOINFORMATICS | 2009年 / 25卷 / 20期

基金：

匈牙利科学研究基金会;

关键词：

UNSTRUCTURED PROTEINS; MOLECULAR RECOGNITION; ENERGY CONTENT;

D O I：

10.1093/bioinformatics/btp518

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

ANCHOR is a web-based implementation of an original method that takes a single amino acid sequence as an input and predicts protein binding regions that are disordered in isolation but can undergo disorder-to-order transition upon binding. The server incorporates the result of a general disorder prediction method, IUPred and can carry out simple motif searches as well.

引用

页码：2745 / 2746

页数：2

共 9 条

[1] Mining α-helix-forming molecular recognition features with cross species sequence alignments [J].

Cheng, Yugong ;

Oldfield, Christopher J. ;

Meng, Jingwei ;

Romero, Pedro ;

Uversky, Vladimir N. ;

Dunker, A. Keith .

BIOCHEMISTRY, 2007, 46 (47) :13468-13477

[2] IUPred:: web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy content [J].

Dosztányi, Z ;

Csizmok, V ;

Tompa, P ;

Simon, I .

BIOINFORMATICS, 2005, 21 (16) :3433-3434

[3] The pairwise energy content estimated from amino acid composition discriminates between folded and intrinsically unstructured proteins [J].

Dosztányi, Z ;

Csizmók, V ;

Tompa, P ;

Simon, I .

JOURNAL OF MOLECULAR BIOLOGY, 2005, 347 (04) :827-839

[4] Coupling of folding and binding for unstructured proteins [J].

Dyson, HJ ;

Wright, PE .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 2002, 12 (01) :54-60

[5]

Garner, 1999, Genome Inform Ser Workshop Genome Inform, V10, P41

[6] Molecular principles of the interactions of disordered proteins [J].

Meszaros, Balint ;

Tompa, Peter ;

Simon, Istvan ;

Dosztanyi, Zsuzsanna .

JOURNAL OF MOLECULAR BIOLOGY, 2007, 372 (02) :549-561

[7] Prediction of Protein Binding Regions in Disordered Proteins [J].

Meszaros, Balint ;

Simon, Istvan ;

Dosztanyi, Zsuzsanna .

PLOS COMPUTATIONAL BIOLOGY, 2009, 5 (05)

[8] ELM server:: a new resource for investigating short functional sites in modular eukaryotic proteins [J].

Puntervoll, P ;

Linding, R ;

Gemünd, C ;

Chabanis-Davidson, S ;

Mattingsdal, M ;

Cameron, S ;

Martin, DMA ;

Ausiello, G ;

Brannetti, B ;

Costantini, A ;

Ferrè, F ;

Maselli, V ;

Via, A ;

Cesareni, G ;

Diella, F ;

Superti-Furga, G ;

Wyrwicz, L ;

Ramu, C ;

McGuigan, C ;

Gudavalli, R ;

Letunic, I ;

Bork, P ;

Rychlewski, L ;

Küster, B ;

Helmer-Citterich, M ;

Hunter, WN ;

Aasland, R ;

Gibson, TJ .

NUCLEIC ACIDS RESEARCH, 2003, 31 (13) :3625-3630

[9] Calmodulin signaling: Analysis and prediction of a disorder-dependent molecular recognition [J].

Radivojac, P ;

Vucetic, S ;

O'Connor, TR ;

Uversky, VN ;

Obradovic, Z ;

Dunker, AK .

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2006, 63 (02) :398-410

← 1 →