Dynamics of Membrane Trafficking Downstream of B and T Cell Receptor Engagement: Impact on Immune Synapses

被引：26

作者：

Yuseff, Maria-Isabel ^{[1
]}

Lankar, Danielle ^{[1
]}

Lennon-Dumenil, Ana-Maria ^{[1
]}

机构：

[1] Inst Curie, INSERM, U932, F-75005 Paris, France

来源：

TRAFFIC | 2009年 / 10卷 / 06期

关键词：

immune synapse; polarity; B cell receptor; T cell receptor; cytoskeleton; membrane trafficking; SUPRAMOLECULAR ACTIVATION CLUSTERS; ANTIGEN RECEPTOR; IMMUNOLOGICAL-SYNAPSE; LIPID RAFTS; POLARIZATION; CYTOSKELETON; RECRUITMENT; INITIATION; EXOSOMES; ADHESION;

D O I：

10.1111/j.1600-0854.2009.00913.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The onset of an adaptive immune response requires the activation of T and B lymphocytes by antigen-presenting cells, through a specialized form of intercellular communication, known as the immunological synapse (IS). In B lymphocytes the IS promotes efficient recognition and acquisition of membrane-bound Ags, while in T cells, it modulates the T cell response upon exposure to peptide-major histocompatibility complexes. In this review, we highlight the similarities that determine B and T cell activation, focusing on immune receptor downstream signaling events that lead to synapse formation. We stress the notion that polarization of T and B lymphocytes characterized by global changes in cytoskeleton and membrane trafficking modulates synapse structure and function, thus determining lymphocyte effector functions and fate.

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收藏

页码：629 / 636

页数：8

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